Finally, increasing levels of PAH were associated with decreased protein expression of IL-10 and increased expression of IFN-γ in a population of 256 subjects (including 171 non-asthmatic and 85 asthmatic subjects); the association strengthened when moving from 24-h to 1-year PAH exposure, thus suggesting a long-term effect [70]. The gene discussed is IFNG; the disease is pulmonary arterial hypertension.