In this respect, Luque-Ramírez et al. (2011) in a randomized clinical trial compared the effect of metformin as an insulin sensitizer with an antiandrogenic contraceptive pill for 6 months and found that patients with PCOS decreased hepcidin levels that might contribute to iron overload through facilating the intestinal absorption of iron [40]. The gene discussed is INS; the disease is polycystic ovary syndrome.