Furthermore, there was no statistically significant difference in the TGF-β1 levels before RT in groups with different comorbidities or the use of medication, e.g. hypertension, hypothyrosis, coronary artery disease (CAD), smoking, diabetes and use of aromatase inhibitors (AI), tamoxifen, angiotensin convertase inhibitors (ACE), acetylsalicylic acid (ASA), or statins. This evidence concerns the gene ACE and coronary artery disorder.