MAPK8 and acute myeloid leukemia: The main finding of the present study is that penfluridol, an antipsychotic drug, exerted an anticancer effect on AML cells harboring FLT3-WT and FLT3-ITD through activating PP2A to deactivate downstream Akt, ERK, and JNK signals and subsequently triggered caspase-mediated cellular apoptosis.