FLT3 and acute myeloid leukemia: Moreover, about 24% of adult AML patients were observed to carry a Juxta-membrane domain internal tandem duplication (ITD) mutation in the FLT3 gene (FLT3-ITD), which leads to uncontrolled cellular proliferation and survival through constitutive activation of FLT3 and subsequent hyperactivation of its downstream signaling pathway [2, 4].