In addition to FLT3-WT AML cells, the apoptosis-inducing effect of penfluridol was more dominant in MV4–11 cells with FLT3-ITD than HL-60 or U937 cells as evidenced by the higher sub-G1 cell accumulation induced by penfluridol (Fig. 2e). The gene discussed is FLT3; the disease is acute myeloid leukemia.