Authors suggest, that CRMO might be suspected in case of a bone pain with or without swelling and without significant features of infection, with the typical radiological findings (lytic areas, sclerosis, new bone formation) and – if the disease is multifocal, with no CRP level elevation, but - if the disease affects one bone – with CRP level greater than 30 g/l and the bone biopsy showing inflammatory changes with no bacterial growth while not on antibiotic therapy [8]. This evidence concerns the gene CRP and chronic recurrent multifocal osteomyelitis.