To investigate the effect of chemotherapy on the expression of Trx 1, Prx 1 and Prx 2 in squamous cervical cancer samples, the expression of Trx 1, Prx 1 and Prx 2 was performed in 35 matched primary squamous cervical cancer biopsies before and after cisplatin-based NACT using immunohistochemistry. This evidence concerns the gene PRRX2 and cervical squamous cell carcinoma.