Quantification of Trx 1, Prx 1 and Prx 2 staining showed that Trx 1, Prx 1 and Prx 2 immunoreactive scores were much higher in squamous cervical cancer compared to basal layer cells of adjacent normal tissues (P = 0.007, P = 0.01, P = 0.01, respectively), (Table 2). This evidence concerns the gene PRRX2 and cervical squamous cell carcinoma.