To explore the role of Trx 1, Prx 1 and Prx 2 in the development of chemo-resistance, the expression of Trx 1, Prx 1 and Prx 2 in pre-chemotherapy cervical cancer tissues between chemotherapy responders and non-responders was examined by immunohistochemistry. The gene discussed is PRRX2; the disease is cervical carcinoma.