PDE5A and atherosclerosis: Clinical trials such as the Pelvic Angiography in Non-responders to PDE5 Inhibitors (PANPI trial), the Zotarolimus–Eluting Peripheral stent system for the treatment of erectile dysfunction in males with suboptimal response to PDE5 inhibitors (ZEN trial) and the Incidence of Male Pudendal Artery Stenosis in Suboptimal Erections Study (IMPASSE trial) are designed to evaluate the angiographic patterns of atherosclerosis in erectile-related arteries in men with suspected or known coronary artery disease or peripheral artery disease with the added potential aim of microvascular stenting [31].