Furthermore, transgenic mice expressing a constitutively active form of AHR under the control of the KRT14 promoter (a gene expressed exclusively in basal KCs) developed AD-like symptoms, including itches, epidermal hyperplasia and enhanced dermal inflammatory infiltrate, similar to mice topically treated for 4 weeks with DMBA and FICZ, two AHR ligands [127,144]. This evidence concerns the gene AHR and Alzheimer disease.