Nevertheless, the AHR agonist tapinarof (GSK2894512), a bacterial metabolite, was able to ameliorate AD [183,184] via the AHR-Nrf2 axis [185] and upregulation of the expression of late differentiation markers in KCs, including FLG, IVL and HNRN via AHR activation [185], very similarly to coal tar [134,186,187]. Here, FLG is linked to Alzheimer disease.