Cancer cells also modify the adhesive capabilities and their mobility through their own factors, hepatocyte growth factor/stromal factor (HGF/SF) and insulin growth factor II (IGF-II), or by matrix proteins such as vitronectin, fibronectin, laminin, and type IV collagen, as well as host-secreted factors such as insulin growth I (IGF-I), interleukin 6 (IL-6) and histamine. The gene discussed is HGF; the disease is cancer.