This was because: (a) There was a significant increase of nuclear NRF2, associated with a slight increase of NQO1 in both cellular fractions; (b) Cal 27 had the strongest increase of nuclear NRF2 among all the cancer cell lines, which was not associated with the corresponding increase of NQO1; and (c) FaDu seems to be unresponsive. Here, NQO1 is linked to cancer.