The human epidermal growth factor tyrosine kinase receptor (EGFR/ERBB) family, which includes four members: HER1 (EGFR, ErbB1), HER2 (Neu, ErbB2), HER3 (ErbB3), and HER4 (ErbB4) have been associated with many human cancers. This evidence concerns the gene ERBB2 and cancer.