ANGPTL8 and obesity due to melanocortin 4 receptor deficiency: Consistent with this result, a previous study showed that the expression of Angptl8 was only upregulated in the liver, white adipose tissue and brown adipose tissue of obesity-induced hyperinsulinemic type 2 diabetes mice, but it was decreased in white adipose tissue of streptozotocin-induced hypoinsulinemic type 1 diabetes mice [37].