CDKN2A and brucellosis: Also, BvrR could be used as a new biomarker for diagnostic chronic infections of brucellosis, as Vitale et al. [60] used the cyclin-dependent kinase inhibitor p16INK4a, in high-risk HPV infections, to identify which low-grade intraepithelial lesion (LSIL) cases were inclined to the progression of the disease and the possible development of cervical cancer.