CD40LG and dengue disease: Our study findings are more robust because the results come from a large patient sample size (118 patients with confirmed (NS1 and/or RT-PCR) or presumptive [single sample positive IgM] dengue infection), with data gathered from a region in the Amazon where the four dengue serotypes are concomitantly present, while specifically excluding patients with other etiologies that are known to contribute to GBWT [5].