TNF and plasma cell myeloma: Also other TNF family members (TNFSF14, FasL, and BAFF) have been found essentially involved in osteoclastogenesis: LIGHT/TNFSF14 increased osteoclastogenesis in multiple myeloma-bone disease [35], FasL enhanced the osteoclasts differentiation [36] and sBAFF contributed to osteoclast differentiation [37] through activation of an alternative NF-κB pathway [38].