To investigate the potential mechanisms of LINC01198 in glioma cells, we predicted the interactions between LINC01198 and RNA-binding proteins by an RNA-protein interaction prediction tool (http://pridb.gdcb.iastate.edu/RPISeq/), and we found that LINC01198 probably binds to NEDD4-1 and PTEN (Supplementary Table 3) (Figure 3A). This evidence concerns the gene NEDD4 and central nervous system cancer.