Our group previously demonstrated for the first time an anti‐fibrotic role of CB1 blockade in non‐metabolic experimental renal fibrosis in mice in the unilateral ureteral obstruction (UUO) model.18 In this model, both the pharmacological blockade and the genetic disruption of CB1 profoundly reduced the development of renal fibrosis. Here, CNR1 is linked to Ureteral obstruction.