The advent of cancer stem cells (CSCs) has provided a novel mechanism for the development and progression of the tumour via differentiating into endothelial cells to contribute to the angiogenesis.50, 51 In addition, a research indicates, for example, that miRNAs, secreted from exosomes, regulate transcription, proliferation, metabolic processing and mRNAs encode vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), angiopoietin1, Ephrin A3, matrix metalloproteinase‐2 (MMP‐2), and MMP‐9 and growth factors in contrast to CD105‐negative CSCs.19 The gene discussed is VEGFA; the disease is neoplasm.