SLC2A1 and cancer: Therefore, cells overexpressing GLUT‐3 may possess a survival advantage and may be clonally selected.21 Moreover, induction of GLUT3 expression has been reported to be a protective mechanism against hypoglycemia in neurons,22 and cancer cells respond similarly to decreased glucose levels.23 Thus, efficient inhibition of glucose uptake in tumors and cancer cells may require simultaneous targeting of both GLUT‐1 and GLUT‐3, and we recently developed the first GLUT‐1/GLUT‐3‐selective compounds.4b, 24