SNHG1 and neoplasm: It is known that lncRNAs play functional roles in a series of steps during tumor development, and they may interact with DNA, RNA, protein and/or various combinations to act as important regulators of chromatin organization and transcriptional as well as posttranscriptional regulation.21 Recent studies indicate that the ncRNA SNHG1 plays important roles in tumor development, and have provided new insights into the biological activities of SNHG1 in tumors (including CRC).22 However, the roles of lncRNAs in CRC tumorigenesis remain incompletely understood.