WNT2 and neoplasm: For instance, Wnt2 promotes the progression of non‐small cell lung cancer through activating the Wnt/β‐catenin pathway.16 Wnt2 also activates the Wnt/β‐catenin pathway and induces cancer metastasis in pancreatic cancer and cervical cancer.17, 18 Moreover, CAFs have recently attracted attention as a source of Wnt2 secretion to promote tumor development.