WNT2 and neoplasm: In CRC tissue, CAFs were also shown to secrete growth factors that stimulate Wnt signaling activity in cancer cells.43 Kramer et al previously presented that Wnt2 expression of colorectal CAFs affected tumor invasion and metastasis from findings of in vitro and in vivo studies.44 In fact, they demonstrated that Wnt2 activated the autocrine canonical Wnt signaling pathway in fibroblast, which was associated with a pro‐migratory and pro‐invasive phenotype.