Recent studies have reported that a variety of signals by cytokines, chemokines, or growth factors derived from CAFs affect the progression of solid cancers.28, 29, 30 In this study, to elucidate the mechanisms by which CAFs regulate CRC progression, we focused on Wnt2, which was found to be highly expressed in CAFs compared with the level in NFs, by RNA‐seq analysis. The gene discussed is WNT2; the disease is colorectal carcinoma.