It also demonstrated that CAFs secreted Wnt2 protein in a paracrine fashion, which activated the Wnt/β‐catenin signaling pathway in cancer cells to promote tumor progression in esophageal cancer.20 In addition, Xu et al19 showed that Wnt2 protein from pancreatic stellate cells enhanced the migration and invasion of pancreatic cancer cells. This evidence concerns the gene WNT2 and familial pancreatic carcinoma.