HTATIP2 and heart failure: While according to our model a balanced abundance of TIP30 and its target eEF1A1 enables compensated cardiac growth during pathological overload, a reduced myocardial TIP30/eEF1A1 ratio like in the late stage of human heart failure promotes exaggerated cardiomyocyte growth and ventricular dysfunction, which could arise from insufficient concomitant myocardial capillary growth.