When linking the TIP30/eEF1A1 ratios to the degree of cardiac hypertrophy and function during pressure overload (see Fig 1), one could infer that a ratio around 1 might allow the development of moderate hypertrophy with compensated heart function, while a ratio < 1 could enable exaggerated hypertrophy and cardiac dysfunction, presumably because of disinhibition of eEF1A1 due to reduced TIP30 levels. Here, HTATIP2 is linked to cardiac hypertrophy.