SIM2 and glioblastoma: This small set of EZH2 targets contained multiple key regulators of neurogenesis, including various transcription factors (HOXA11, HOXB9, NR6A1, SIM2, EMX2), the PRC1 component CBX2, and other proteins involved in neuronal function (CACNG8, SLC30A3, TENM4) or GBM development (PREX1, BCL2; Fig 2E).