EZH2i led to EMX2 de‐repression in nine cell lines from six cancer types, suggesting that cancer cells may generally use EZH2 to silence EMX2. Taken together, these results indicate that transformation‐driven redistribution of EZH2 leads to aberrant regulation of key homeotic genes in neural cells, inducing silencing of a forebrain‐specific transcription factor and ectopic expression of spinal cord‐specific regulators. This evidence concerns the gene EMX2 and cancer.