The mechanism of how CAFs promote tumor initiation and progression are not clear, however, they are capable of producing multiple soluble factors such as IL-1 and monocyte chemotactic protein-1 (MCP-1) (to induce inflammation), matrix metalloprotein (MMP) and vascular endothelial growth factor (VEGF) (to interact with microvasculature), transforming growth factor-β (TGF-β), hepatocyte growth factor (HGF) and stromal cell derived factor 1 (SDF1) (to induce tumor cell proliferation and invasion) [14]. Here, HGF is linked to neoplasm.