MUC1 and adenocarcinoma: In this regard, a multi-functional pan-adenocarcinoma associated molecule MUC1 appears to be an excellent target for inhibition by mAbs, which could potentially act as inhibitor of metabolic checkpoint in tumor cells and immune checkpoint on T cells, while additionally blocking invasiveness and metastasis of tumor cells bearing MUC1 [69, 72, 73, 97].