Macrophages were implicated in the pathogenesis of AMD based on multiple studies, among them are the presence of macrophages in the vicinity of AMD lesions [44, 45, 64, 65], proangiogenic human and rodent macrophages' effect in vitro and in the rodent model of LI-CNV [18, 22, 66], and the reduced size of experimental CNV following inhibition of the CCR-CCL2 signaling pathway and monocyte recruitment [30, 67]. The gene discussed is CCL2; the disease is age-related macular degeneration.