In accordance with the high levels of MCP-1, the ligand for CCR2 was detected in the aqueous humor of patients with AMD [42, 43], and macrophages have been found in the vicinity of drusen areas of retinal pigment epithelium (RPE) atrophy, Bruch's membrane rupture, and choroidal neovascularization (CNV) in histological sections from AMD eyes [44–49]. This evidence concerns the gene CCR2 and age-related macular degeneration.