Gliflozins are regarded as a promising adjuvant therapy in T1D, since clinical trials (using empa-, sota-, dapa-, or canagliflozin) revealed a positive impact on HbA1C levels, weight management, and daily insulin doses during treatment protocols from 4 to 26 weeks [6–8, 31, 32]. This evidence concerns the gene INS and type 1 diabetes mellitus.