The NOCTURNIN gene regulates the circadian cycles and binds them to the metabolic rhythms; its involvement in lipid metabolism, adipogenesis, glycaemic homeostasis, and inflammation entails that it plays a role in promoting metabolic alterations [5–7]. Nocturnin-knockout mice show greater glucose tolerance and insulin sensitivity as well as increased resistance to obesity and hepatic steatosis, likely due to altered absorption of intestinal fats or to their consumption in alternative metabolic cycles [3]. The gene discussed is NOCT; the disease is obesity due to melanocortin 4 receptor deficiency.