Whether the identified VUS will be classified as pathogenic or not, SEMA4A and CNGA1 share some biological pathways with ARMS2 and IL-8, suggesting that these genes may interact together and contribute to increase the susceptibility to develop neovascular lesions, which may be more facilitated to grow in RP cases because of photoreceptor cells degeneration, RPE changes and choriocapillaris damage. Here, CXCL8 is linked to retinitis pigmentosa 1.