TPO and hyperthyroidism: Similarly, 93/118 (78.8%) subjects in group A2 had either anti-TPO or anti-Tg prior to the onset of subclinical/overt hyperthyroidism compared to 81/118 (68.6%, p= 0.1033) with anti-TPO and 58/118 (49.2%, p<0.0001) with anti-Tg.