As shown in Figure 3, 126/152 (82.9%) subjects in group A1 had either anti-TPO or anti-Tg prior to the onset of subclinical/overt hypothyroidism compared to 111/152 (73.0%, p= 0.0522) with anti-TPO and 83/152 (54.6%, p<0.0001) with anti-Tg. This evidence concerns the gene TG and hypothyroidism.