Even though our study was limited to 2 years, our results correlate with a study performed by Hutfless et al. that showed the preexistence of anti-TPO and anti-Tg autoantibodies 7 years prior to the concise diagnosis of Hashimoto's (66% and 57% for anti-TPO and anti-Tg, respectively) and Graves' disease (57% and 47% for anti-TPO and anti-Tg, respectively) for 174 patients [24]. This evidence concerns the gene TPO and Graves disease.