Linear regression models with the global FDG-PET or PiB-PET signal to reference region (cerebrum (C) to cerebellum or to pons or to thalamus ratios) as dependent variables with KLK6, KLK8 or KLK10 as independent variables, respectively, were calculated in a sub-cohort of 14 AD patients. This evidence concerns the gene KLK10 and Alzheimer disease.