A study has shown that cerebral ischemia and reperfusion in rat hippocampi could induce JNK undergoing complete inactivation following the intense activation, in which after 4 h of reperfusion in rat hippocampi, the activity of DUSP8 was significantly upregulated, accompanied by the dephosphorylation of JNK. This evidence concerns the gene MAPK8 and brain ischemia.