Figure S2), suggesting that OOS does not affect overall tumor growth or survival, which correlates with the lack of effect on cell viability (Figure 1(a)). Moreover, we observed a significan change in GBM1 tumors in the expression of the marker NESTIN, associated with GBM CSCs, which was not observed in GBM3 tumors (Figure 2(d)). The gene discussed is NES; the disease is glioblastoma.