Figure S2), suggesting that OOS does not affect overall tumor growth or survival, which correlates with the lack of effect on cell viability (Figure 1(a)). Moreover, we observed a significan change in GBM1 tumors in the expression of the marker NESTIN, associated with GBM CSCs, which was not observed in GBM3 tumors (Figure 2(d)). This evidence concerns the gene NES and neoplasm.