STAT3 and Hepatic fibrosis: In addition, it has been reported that Asiatic acid can ameliorate CCl4-induced liver fibrosis in rats by regulating PI3K/AKT/mTOR, Bcl-2/Bax, Nrf2/ARE, NF-κB/IκBα and JAK1/STAT3 signaling pathways [47, 48].