Comparing the results of the analysis with human RNA-seq data from TCGA AML cohort displayed enrichment of U2AF1-induced splicing alterations in processing genes, ribosomal genes, and recurrently mutated MDS and AML-associated genes (e.g., NPM1, BCOR, and KMT2D). The gene discussed is KMT2D; the disease is acute myeloid leukemia.