In AML with balanced 11q23 translocations, many tumor suppressor miRNAs, targeting known oncogenes, were downregulated, e.g., miR-34b (targeting CDK4 and CCNE2), miR-15a (targeting BCL2), let-7 family (targeting RAS genes), and miR-196 (targeting HOX genes). This evidence concerns the gene BCL2 and acute myeloid leukemia.