TP53 and acute myeloid leukemia: In the miRNA expression signature specific for R172 IDH2-AML, members of miR-125 family (including miR-125b which targets the tumor suppressor gene TP53 and inhibits myeloid differentiation), and two microRNAs not associated with cancer but involved in embryonal stem-cell differentiation, miR-1 and miR-133, were upregulated.