25 genes, including 7 HOX family members, POU4F1, TSPAN7, MYH11, RUNX1T1, RUNX3, CD34, and MN1, were reported as AML-specific by at least 8 independent studies. HOX/TALE expression was increased in AML with normal cytogenetics, NPM1 and FLT3 mutations, and 11q23 abnormalities involving the KMT2A gene. Here, NPM1 is linked to acute myeloid leukemia.