CEBPA and acute myeloid leukemia: Having a set of nearly 300 samples, the authors were able to distinguish a unique gene expression signature for AML with CEBPA mutations. CEBPA gene, mutated in 5% to 15% of all AML cases encodes a critical regulator of hematopoietic stem-cell maintenance and myeloid differentiation, therefore unique gene expression pattern was not unexpected for samples with the loss-of-function CEBPA mutation.