Comparing to KMT2A-ALL, overexpression of CEBPB, CEBPA, KIT, MADH2, MITF, FES and SPI1 (former PU.1) oncogenes, and MNDA, encoding the myeloid cell nuclear differentiation, was noted in KMT2A-AML. Here, SPI1 is linked to acute lymphoblastic leukemia.