AFDN and acute promyelocytic leukemia: Signature specific for APL included genes related to hemostasis (PLAU, SERPING1, ANXA8, and PLAUR), resistance to apoptosis (TNFRSF4, AVEN, and BIRC5), impairment of retinoic acid-stimulated cell differentiation (TBL1X, CALR, and RARRES3) and resistance to chemotherapy (CYP2E1, EPHX1, and a group of metallothionein (MT) genes). MLLT4 (present AFDN, Afadin), one of KMT2A fusion partners, was among the genes with unique expression profile in t(8;21), which suggested similar mechanism of pathogenesis with t(6;11).