Two the most differentiating genes between AML +8 and CN-AML were MLLT2 (present AFF1 (AF4/FMR2 Family Member 1), upregulated in CN-AML) encoding regulator of transcription and chromatin remodeling, and FABP5 (upregulated in AML +8), encoding protein involved in fatty acid metabolism. The gene discussed is AFF1; the disease is acute myeloid leukemia.