Wilms tumor 1 antisense RNA (WT1-AS) lncRNA was found as typical of FLT3-ITD signature whereas downregulation of HOXB-AS3 lncRNA was noted in CEBPA-mutated AML. RUNX1 mutation was associated with the increase of lncRNAs located in the proximity of lymphoid marker genes (e.g., BLNK), the immunoglobulin heavy locus (IGH) complex, and vault RNA 1-1 (VTRNA1-1), which was linked with multidrug resistance. The gene discussed is BLNK; the disease is acute myeloid leukemia.