Mutations in IDH1 and IDH2 genes, encoding two isoforms of the nicotinamide adenine dinucleotide phosphate (NADP)-dependent isocitrate dehydrogenases, cytosolic and mitochondrial, respectively, occur in 33% of CN-AML patients and confer unfavorable prognosis [144]. Here, IDH2 is linked to acute myeloid leukemia.