In addition to RUNX1–RUNX1T1 fusion, typical of t(8;21) AML, the patient harbored two additional translocations with the contribution of VPS13B gene, a causative gene of Cohen syndrome, encoding vacuolar protein sorting 13, forming TM7SF3–VPS13B and VPS13B–RUNX1 fusion genes. The gene discussed is RUNX1; the disease is acute myeloid leukemia.