CARD8 and acute myeloid leukemia: AML patients with high hsa_circ_0075001 expression, presented upregulation of ribosomal protein genes, increase of total NPM1 expression, and downregulation of genes involved in the Toll-like receptor (TLR) signaling pathway and genes targeted by miR-181 (e.g., CARD8, CASP1, MSR1, SLC11A1, TLR4), which is deregulated in CN-AML.