Comparing subpopulations of cells extracted from 163 NK-AML samples, the authors identified 52 genes discriminating the LSC-enriched subpopulations (CD34+/CD38-) from the leukemic progenitor cell (LPC)-enriched subpopulations (CD34+/CD38+), among others genes involved in early hematopoiesis, e.g., VNN1, RBPMS, SETBP1, GUCY1A3, MEF2C, and HOPX. Here, CD38 is linked to acute myeloid leukemia.