The unique crosstalk between POS and AML cells was mediated by cytokines and chemokines, angiopoietin 1, secreted phosphoprotein 1, and SDF-1, encoded by ANGPT1 (former Ang-1), SPP1 (former OPN), and CXCL12 genes, respectively. This evidence concerns the gene ANGPT1 and acute myeloid leukemia.