The authors identified a set of class discriminating genes, which included genes specifically overexpressed in particular AML FAB types, e.g., AML M2, was characterized by increased expression of genes coding for cell surface antigens (CD34; CD19), proteins regulating developmental processes (ROBO1, TWSG1, and PELI2) and transcription factor POU4F1. This evidence concerns the gene TWSG1 and acute myeloid leukemia.