NPM1 and acute myeloid leukemia: In older (> 60 years) CN-AML patients with RUNX1 mutation and wt NPM1, genes normally expressed in primitive hematopoietic cells (e.g., BAALC, CD109, GNAI1, HGF,  and FHL1) and early lymphoid precursors, B-cell progenitors (e.g., DNTT, BLNK, FOXO1, and FLT3), were upregulated whereas myelopoiesis promoters, such as CEBPA, components of neutrophil granules (AZU1, MPO, and CTSG), were downregulated.