Interestingly, genes which are frequently mutated in AML, but not mutated in CG-SH (e.g., NPM1, GATA2, IDH2, RUNX1, and TP53), were upregulated in the studied cell line, however, their levels of expression remained within the ranges observed for 55 AML patients. The gene discussed is IDH2; the disease is acute myeloid leukemia.