In older (> 60 years) CN-AML patients with RUNX1 mutation and wt NPM1, genes normally expressed in primitive hematopoietic cells (e.g., BAALC, CD109, GNAI1, HGF,  and FHL1) and early lymphoid precursors, B-cell progenitors (e.g., DNTT, BLNK, FOXO1, and FLT3), were upregulated whereas myelopoiesis promoters, such as CEBPA, components of neutrophil granules (AZU1, MPO, and CTSG), were downregulated. This evidence concerns the gene CTSG and acute myeloid leukemia.