Then, a common gene expression signature, enriched in homeobox genes (MEIS1, HOXA4, HOXA5, HOXA7, HOXA9, and HIOXA10), was determined for all acute leukemias with KMT2A fusion, irrespectively of their lineage (myeloid or lymphoid), by Ross et al. [68]. This evidence concerns the gene HOXA4 and acute leukemia.