Extending their research to a larger AML patient cohort and normal CD34+ transcriptome, the authors identified four new types of tumor-specific chRNAs recurrently expressed in AML samples (TRIM28-TRIM28, DHRS7B-TMEM11, PLXNB-BLRD1, and SLC16A3-METRNL). Here, TRIM28 is linked to acute myeloid leukemia.