Doublecortin-like kinase 1 (DCLK1) is often overexpressed in pancreatic cancer and is coexpressed with other PDAC CSC markers, and recent studies indicate that DCLK1+ PDAC cells can initiate pancreatic tumorigenesis in the presence of mutation and inflammation [8, 9]. Here, DCLK1 is linked to pancreatic neoplasm.