Furthermore, an association with various estrogen-dependent genes such as ANXA1, PIWIL2, CASP4, ESR1/ESR2, PLAC1, and SOCS2, has been shown in breast cancer—however, up to date, no such data concerning adenocarcinomas of the esophagogastric junction have been published [54]. The gene discussed is SOCS2; the disease is breast cancer.