The most comprehensively studied pathways involved in GBM invasion include PI3K/Akt, Wnt/ß-catenin, Hedegehog, TGFß, and Tyrosine kinase receptors, which are involved in the activation of EMT-related cellular processes to promote tumor cell dissemination and invasion [73, 74]. The gene discussed is PIK3CA; the disease is neoplasm.