FLT3 and acute myeloid leukemia: In addition, the AML blasts of more than half of patients with WT1 (n=25/48, 52%) and FLT3-ITD (n=28/52, 54%) mutations had a normal karyotype at diagnosis; these percentages were significantly higher than those in patients without mutations in each of the two genes (p<0.0001, Table 1).