RUNX3 revealed significantly lower protein level in glioblastomas compared to grade II tumours (Kruskal-Wallis test, p=0.005) and a tendency of lower GBM RUNX3 protein level compared to grade III astrocytomas (Kruskal-Wallis test, p=0.124), Figure 2(b). This evidence concerns the gene RUNX3 and neoplasm.