Other therapeutic options include biologic agents interfering with specific molecules of cell signaling pathways, e.g., the mammalian target of rapamycin (mTOR) and vascular endothelial growth factor (VEGF), with everolimus and sunitinib, respectively, both approved for pancreatic NENs [27, 28]. The gene discussed is VEGFA; the disease is pancreatic neuroendocrine neoplasm.