Other therapeutic options include biologic agents interfering with specific molecules of cell signaling pathways, e.g., the mammalian target of rapamycin (mTOR) and vascular endothelial growth factor (VEGF), with everolimus and sunitinib, respectively, both approved for pancreatic NENs [27, 28]. Here, MTOR is linked to pancreatic neuroendocrine neoplasm.