TRIM33 and adenocarcinoma: Examples included, hyaluronan-binding protein 2, galectin-3-binding protein, phosphatidylinositol-glycan-specific phospholipase D. The lowest discovered plasma proteins found were in the ρg/ml concentration range and included the E3 ubiquitin-protein ligase TRIM33 that is known to be specifically expressed in colon adenomas and adenocarcinomas and is thought to be a regulator of TGF-β receptor signaling pathway [44].