The two different processes at the base of the reduction of TF activity in A375 and SK-MEL-28 melanoma cells may be reasonable since even if both cell lines derive from human metastatic cutaneous melanoma cells bearing V600E mutations in BRAF gene, they differ in proliferation, migration and invasion rates, with the A375 showing a more aggressive phenotype compared to SK-MEL-28 [29]. The gene discussed is BRAF; the disease is melanoma.