The binding of activated factor VII (FVIIa) to TF expressed by tumor cells releases the negative regulatory control of protease-activated receptors (PARs), in particular PAR-1 and -2, resulting in the activation of several mitogen-activated protein kinase (MAPK) pathways, ultimately promoting angiogenesis, cell survival and metastasis [3]. The gene discussed is TF; the disease is neoplasm.