Heterozygous and biallelic variants in TNFRSF13B cause a form of common variable immunodeficiency (CVID2; MIM: 240500), characterized by hypogammaglobulinemia and recurrent infections, including otitis media, respiratory tract infections, and gastrointestinal tract infections20,21. This evidence concerns the gene TNFRSF13B and common variable immunodeficiency.