For example, ApoE e4 (apolipoprotein E-epsilon4) is strongly linked in isoform-dependent manner with sporadic AD51,52 and ARHL53,54, possibly through changes in cholesterol homeostasis55 or hypercholesterolemia in the main vasculature and associated atherosclerosis56,57. The gene discussed is APOE; the disease is familial hypercholesterolemia.