PAPSS2 and skeletal dysplasia: Among these target genes, COL2A149, HAPLN150, COL9A251, COL11A152, MATN3 (encoding matrilin 3)53, PAPSS2 (encoding 3′-phosphoadenosine 5′-phosphosulfate synthase 2)54,55, and FGFRL1 (encoding fibroblast growth factor receptor like 1)56 were previously identified as skeletal dysplasia responsible genes.