PFN2 and Alzheimer disease: In addition, chaperones like HSP 90 protein, α-crystallin B chain that are commonly abundant in AD in the region of senile plaques38; signal transduction proteins such as 14-3-3 β/α, 14-3-3 ζ/δ, synaptotagmin, Dihydropyrimidinase-related protein 2 and profilin-2; and membrane trafficking proteins including dynamin, dynein, and clathrin were also identified in L-PGDS-treated extractions of AD brain tissues (Table 1).