According to the different intrinsic subtypes of breast cancer, we observed that patients with luminal-like breast cancer had comparatively lower TIL infiltrations (71% low or moderate and only 29% high infiltration), whereas in luminalHER2-like, HER2-positive and TNBC tumors, stromal TILs were more frequent and high infiltration was observed in 53%, 71% and 60%, respectively (Fig. 4a). The gene discussed is ERBB2; the disease is breast cancer.