Considering that CASP8 -652 InsDel and Asp302His have previously been described to promote survival of T-lymphocytes, which suggests a potential immunomodulatory role of these genetic variants4, we analyzed intratumoral and stromal TILs among the tumor tissues of all study patients and correlated these findings with the underlying caspase 8 genotypes. The gene discussed is CASP8; the disease is neoplasm.