Quantification of lipid peroxidation, oxidative degradation of lipids, by 4-HNE staining revealed a ~40% increase in 3xTg-AD × NCLX-cKO mice brains, as compared with 3xTg-AD × Camk2a-Cre mice (Fig. 5k, l). The gene discussed is SLC8B1; the disease is Alzheimer disease.