BACE1 and Alzheimer disease: However, we did observe a reduction in BACE1 expression in prefrontal cortex samples isolated from 3xTg-AD × NCLX-overexpressing mice as compared with AD mutant mouse controls (Fig. 3m; Supplementary Fig. 7J’), a result that correlates with our findings of increased BACE1 expression in the NCLX-null AD model (Fig. 2m).