RIPA-soluble, and insoluble Aβ1–40 levels were reduced by >50% in 3xTg-AD × NCLX-overexpressing mice and likewise Aβ1–42 levels were significantly decreased, as compared with 3xTg-AD × Camk2a-tTA mice (Fig. 3i, j). The gene discussed is CAMK2A; the disease is Alzheimer disease.