We did not observe any changes in prefrontal cortex expression of total APP, α-secretase (ADAM-10), or γ-secretase complex components (presenilin 1, PS1; APH1 subunit; and nicastrin) between 3xTg-AD brains and NCLX-cKO × 3xTg-AD samples. The gene discussed is APH1A; the disease is Alzheimer disease.