Moreover, miRNA methylation showed better performance in detecting early-stage pancreatic cancer than established biomarkers such as carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA)24 (Fig. 4b, c, See Supplementary Fig. 18, and Supplementary Table 5). Here, CEACAM5 is linked to pancreatic neoplasm.