APP and Cognitive impairment: miR-181a overexpression in the brain rescues spatial learning and memory deficits and ameliorates amyloid plaque deposition in AD developing APP/PS1 mice, inversely suggesting that miR-181a decline along with AD development contributes to cognitive impairment and Aβ accumulation, and also implying that miR-181a may be considered as a therapeutic target for AD therapy.