Pericyte degeneration and BBB breakdown have been found in some neurological disorders, such as spinal cord injury [6], including Alzheimer’s disease (AD) [7, 8], a neurodegenerative disease characterized by abnormally elevated amyloid β-peptide (Aβ), tau pathology and neuronal loss, which lead to progressive cognitive decline, and ultimately, dementia [9, 10]. Here, MAPT is linked to Alzheimer disease.